Pair Name	Tanshinone IIA, Imatinib
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	MKI67	hsa4288
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	Jurkat	Childhood T acute lymphoblastic leukemia	Homo sapiens (Human)	CVCL_0065
In Vivo Model	TBI-152 cells (4×10⁶) were injected into the right flank of the mice.
Result	The results revealed that Tan IIA enhanced the inhibitory effect of imatinib on TIB‑152 cell proliferation, migration and invasion, and induced apoptosis, which may be associated with inhibition of the PI3K/AKT/mTOR signaling pathway.